Research in our lab uses a combination of cellular and molecular approaches in the analysis of T-cell responses to bacterial pathogens. Many virulence factors have been identified which allow bacteria to survive and replicate within the mammalian host...
My research focuses on understanding the relationship between genotype and phenotype, with a special interest in how biochemistry, molecular design, and wiring can allow cells to process information from their environment and respond appropriately. By...
Why do we grow old? Why does aging cause disease? Can we slow aging or even reverse it? These are some of the greatest unsolved questions in biology. Advances in technology are allowing us to probe these questions more deeply and more rapidly than ever...
We seek to use the vast knowledge of biology to predictably design biological systems to enhance our fundamental understanding and to provide solutions for real world problems.
Current projects use mammalian cells, simple eukaryotes and prokaryotes....
Despite years of research, tuberculosis remains a leading killer, causing almost two million deaths each year worldwide. While the treatment for drug-sensitive disease is effective, it requires supervised therapy for extended periods of time and remains...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the host that are largely unexplored. These range from knowledge of the basic biology of individual strains...
Tissue Immune Regulation
The successful immune response is designed to cope with tissue malfunction or infection and is self-limiting in nature. Immune cells may exert a broad spectrum of context-dependent immune responses in a highly flexible manner...
in situ single-cell transcriptomic techniques offer the exciting ability to characterize gene expression within single cells in their native tissue context. With these technologies, it is possible to discover different types and states of cells in...
The Lieberman laboratory studies the innate and adaptive immune response to infection and cancer. They seek to understand how cytotoxic T lymphocytes and NK cells provide immune protection in some conditions and fail to function or cause immune pathology...
We are working to understand how cells respond to pathogens, and how these signaling pathways can be harnessed for new potential therapies to treat cancer and autoimmune diseases. Importantly, many critical aspects of the cellular response to infection...
