My laboratory uses a stem cell based approach to understand neurodegenerative diseases, particularly orphan diseases such as Spinal Muscular Atrophy, so that we can identify potentially new therapeutic targets. Our work is based on using disease relevant...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
Internal and external senses
We study internal sensory systems using molecular and genetic approaches. The vagus nerve is an essential body-brain communication axis that controls vital functions of the respiratory, cardiovascular, digestive, and immune...
The overall goal of our research is to understand the role of the tumor microenvironment, including the tumor vasculature and matrix, in tumor growth and response to therapy, to develop novel strategies to manipulate the tumor microenvironment, and to...
Research in the Hwang Laboratory is anchored on the immense phenotypic, temporal and spatial heterogeneity of tumor ecosystems and the many insights that can only be gleaned by studying these systems at the level of their individual components—single...
Our laboratory focuses on understanding the role that mitochondria play in mammalian aging and disease. Mitochondria are dynamic organelles that provide cells with energy even during dramatic changes in diet, stress and development. Mitochondria are also...
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
Our research focuses on deciphering the molecular mechanisms of metabolic disease and dysfunction, and using this information to develop targeted therapeutic strategies. Dysfunction in a particular cellular locale – the mitochondrion – is implicated most...
