Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...
Though much of what defines a human is encoded in the sequence of our DNA, many additional factors influence how this genetic information is manifest. For example, heritable epigenetic information contained within chromatin, the higher-order structure...
The Raghavan Lab at Dana-Farber Cancer Institute and Harvard Medical School is a basic and translational oncology lab focused on understanding mechanisms of cell state regulation in cancer, evaluating how cell state plasticity influences therapeutic...
The Abudayyeh-Gootenberg lab, based at the Mass General Brigham Gene and Cell Therapy Institute, Beth Israel Deaconess Medical Center, and Harvard Medical School, is dedicated to exploring programmable systems in biology for the development of molecular...
The Pu laboratory studies cardiovascular development and disease, with a goal of developing new therapies for pediatric heart disease. We integrate molecular biology, functional genomics, cardiac physiology, genome editing, stem cell biology...
My lab studies the development and evolution of cancer through analysis of intratumoral genetic, transcriptional, and immunological heterogeneity. Our work lies at the intersection of computational biology, molecular biology, and medicine: Using...
We seek to elucidate mechanisms of disease and develop novel therapeutics through understanding underlying processes of innate and adaptive immunity that cause disease or are responsible for organ repair and regeneration. The major areas of interest of...
Our systems immunology and regulatory genomics lab is a multidisciplinary research group that employs genetics and a variety of quantitative multi-omics techniques to enhance our comprehension of the mechanisms of immune-mediated diseases. We explore how...
Taekjip Ha analyzes single molecules to understand how they act in complex biological systems. Ha and his team combine sophisticated biophysical manipulation techniques with fluorescence imaging to visualize and manipulate protein, RNA, and DNA molecules...
The cell surface is a central hub of biological processes, transducing information from the cell’s surroundings to enable dynamic and specific responses to their local environment. Myriad human diseases result from the dysregulation of extracellular and...
