The Chao Lab seeks to understand the molecular mechanisms underlying membrane shape. We apply an approach integrating structural biology, biophysics, bioinformatics and physiology, to investigate membrane remodeling and ultrastructure in mitochondria and...
Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...
Though much of what defines a human is encoded in the sequence of our DNA, many additional factors influence how this genetic information is manifest. For example, heritable epigenetic information contained within chromatin, the higher-order structure...
The broad focus of the Alt lab is the elucidation of mechanisms that generate antigen receptor diversity in the Immune system and mechanisms that maintain genomic stability in mammalian cells. Over the past decade we have developed remarkably sensitive...
The Abudayyeh-Gootenberg lab, based at the Mass General Brigham Gene and Cell Therapy Institute, Beth Israel Deaconess Medical Center, and Harvard Medical School, is dedicated to exploring programmable systems in biology for the development of molecular...
My lab studies the development and evolution of cancer through analysis of intratumoral genetic, transcriptional, and immunological heterogeneity. Our work lies at the intersection of computational biology, molecular biology, and medicine: Using...
We seek to elucidate mechanisms of disease and develop novel therapeutics through understanding underlying processes of innate and adaptive immunity that cause disease or are responsible for organ repair and regeneration. The major areas of interest of...
Our lab is broadly interested in the biology of immune proteins found throughout nature. Bacteria have evolved numerous defenses against phage, including CRISPR-Cas systems, and while these predominantly function as RNA-guided nucleases, additional...
Our lab’s long-term goal is to create a novel gene therapy-based therapeutic to preserve and restore healthy vision for patients suffering from diseases that cause irreversible blindness. In particular, we study a disease called Retinitis Pigmentosa (RP)...
We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...
