Our research will integrate organic chemistry, chemical biology, and cancer biology to develop covalent compounds that allow chemical rescue of somatic mutations in cancer currently deemed “undruggable”. Somatic mutations, particularly in proto-oncogenes...
Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
Research in the Wolfson lab is focused on understanding how we sense our internal environment. Sensory neurons that innervate internal organs have cell bodies that reside in the dorsal root ganglia, the DRG sensory neurons. These neurons must respond to a...
My lab works at the intersection of virology, immunology and systems biology. Our core mission is to uncover global principles in virology by decoding hundreds of viral genomes. Our projects revolve around a central question: how have the compact genomes...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
The research efforts in the laboratory are directed towards understanding the molecular basis of pathogenesis of human infections caused by opportunistic gram-negative bacteria. We have used Pseudomonas aeruginosa as a model opportunistic pathogen...
Internal and external senses
We study internal sensory systems using molecular and genetic approaches. The vagus nerve is an essential body-brain communication axis that controls vital functions of the respiratory, cardiovascular, digestive, and immune...
My research program focuses on studying mRNA translation in parasites that significantly burden global health, including Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing translation initiation factors and...
Resistance to antibiotics is arguably one of the most important challenges facing human health in the coming decades. It can arise through the acquisition of new genes or through mutations in existing genes that block antimicrobial action. Resistance is...
