The van Opijnen Lab works at the intersection of microbial systems biology, functional genomics, and computational modeling. Our central focus is understanding how bacterial pathogens survive the combined assault of host immunity and antibiotic treatment...
Our laboratory pursues both basic and translational studies to understand and treat infections caused by intestinal bacteria. Areas of interest described below include the impact of intestinal pathogens on host metabolism and nutrition, development of...
William Shih is a Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Institute and a Founding Core Faculty member at the Wyss Institute...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
The research efforts in the laboratory are directed towards understanding the molecular basis of pathogenesis of human infections caused by opportunistic gram-negative bacteria. We have used Pseudomonas aeruginosa as a model opportunistic pathogen...
Resistance to antibiotics is arguably one of the most important challenges facing human health in the coming decades. It can arise through the acquisition of new genes or through mutations in existing genes that block antimicrobial action. Resistance is...
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
The long-term goal of the Devlin lab is to understand and control the chemistry of human-associated bacteria in order to uncover how the microbiome affects human health and disease.
We are not alone. The human body harbors more bacterial cells than human...
