Our laboratory pursues both basic and translational studies to understand and treat infections caused by intestinal bacteria. Areas of interest described below include the impact of intestinal pathogens on host metabolism and nutrition, development of...
Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...
The bithorax complex in the fruit fly is a cluster of “homeotic” genes which confer distinct identities on the different segments of the fly. The genes are strikingly aligned on the DNA in the order of the segments they affect. Many of the interactions...
Bioenergetics and Energy Homeostasis
My laboratory studies the molecular basis of bioenergetics in health and disease, i.e., how we coordinate metabolic demands and control energy homeostasis, and how the processes go wrong in metabolic diseases, cancer...
Our laboratory studies how chromosome behavior and positioning influence genome function and evolution, with implications for gene regulation, genome stability, and diseases such as cancer and neurodevelopmental disorders. Using mammals, Drosophila, and...
Apoptosis is a prevalent and important cell fate during development and homeostasis of multicellular organisms. The long-term goal of our research is to understand the regulation and execution of apoptosis, using the powerful genetic and molecular...
Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level...
Our research is devoted to understanding the regulation of neuronal connectivity and synaptogenesis. We combine genetic approaches with molecular biology, sophisticated imaging, and behavioral assays to understand the cell biological mechanisms necessary...
Physiological and Regenerative Homeostasis in Drosophila
The central objective of developmental biology is to understand how organisms grow to adulthood. In the past 30 years, studies using genetically tractable model systems have led to a detailed...
Mutational processes in cancer and normal cells; development of computational methods for genome and epigenome analysis.
We employ computational and statistical approaches to study various types of somatic mutations that arise in cancer cells and neurons...
