Analysis of chromatin organization and epigenetic gene regulation in health and disease
We study epigenetic regulators using genetics, genomics and proteomics. The factors we study include the Polycomb and Trithorax Groups in both flies and humans, and...
To maintain the differentiated tissues in any organism, cell-type specific genes must remain ‘on' for the lifetime of the organism in one cell type, and ‘off' for the lifetime of the organism in other cells. Thus the same gene, with the same primary DNA...
Dr. Kaelin's research seeks to understand how, mechanistically, mutations affecting specific genes cause cancer, with a particular focus on particular tumor suppressor genes. His laboratory is currently focused on studies of the VHL and RB tumor...
My laboratory is focused on understanding nervous system disease using molecular genetic strategies, beginning with human patients and proceeding through in vitro and modeling studies, with the ultimate goal of improving diagnosis, management and...
Research in our lab revolves primarily around aging, lifespan control and rejuvenation.
We also have had longstanding interests in selenium and redox biology.
Understanding mechanisms of lifespan control through longevity signatures
Mice live 3 years...
The molecular mechanisms underlying neurodegeneration in human disorders like Alzheimer's disease and Parkinson's disease remain mysterious, in part because genetic analysis in patients and vertebrate models is laborious. Disease models in simpler...
The Adelman lab aims to elucidate how cells react in a rapid yet balanced manner to external signals, at the transcriptional and epigenetic level. We use a combination of genomics, genetics and biochemistry to study the dynamics of gene expression, with a...
