Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
Our laboratory is focused on studying neuroblastoma, an embryonically derived pediatric tumor of the peripheral sympathetic nervous system. We are interested in the following general areas: 1) identifying molecular targets that can be translated into...
The Segel lab is interested in the evolution of mammalian lifespan. From single cells to whole organisms, we are interested in the molecular pathways that govern the pacing of postnatal mammalian development.
We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to...
Our laboratory pursues both basic and translational studies to understand and treat infections caused by intestinal bacteria. Areas of interest described below include the impact of intestinal pathogens on host metabolism and nutrition, development of...
The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
The overall theme of our lab is the regulation of energy homeostasis in mammalian systems, with special reference to adipose and muscle tissues. While we have long been interested in diabetes and obesity, our current interests extend to muscle disorders...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
During development, signaling pathways initiated by extracellular growth factors regulate and coordinate proliferation, differentiation, migration and survival. Understanding growth factor signaling pathways identifies critical steps in development and...
