We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
Our lab is focused on development and application of proteomics-based methods for in-depth analysis of key molecular events in tumorogenesis. Given the highly dynamic nature of biological processes, we are particularly interested in novel and robust...
Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...
Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...
Taekjip Ha analyzes single molecules to understand how they act in complex biological systems. Ha and his team combine sophisticated biophysical manipulation techniques with fluorescence imaging to visualize and manipulate protein, RNA, and DNA molecules...
Vik Khurana M.D. Ph.D. is the inaugural incumbent of the Tracy T. Batchelor Endowed Chair in Neurology at MassGeneral Brigham, Chief of the Movement Disorders Division at Brigham and Women's Hospital and Associate Professor of Neurology at Harvard Medical...
The Farnung Lab aims to answer key mechanistic questions at the intersection of chromatin and transcription. We employ biochemical, biophysical, and structural biology approaches to understand how the transcription machinery, histone modifying enzymes...
How do cells sharing the same DNA produce drastically distinct phenotypes? In one organism, the same genome allows for the development of different tissues, controlled cell cycle progression, and specialized responses to environmental stimuli. This occurs...
