A critical step in eukaryotic gene regulation is the control of transcription across the chromatin template. While transcription has been extensively studied for many years, there are still many mysteries regarding its function and regulation. Furthermore...
Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level...
Transcriptional regulation in response to environmental and developmental cues is mediated by the combinatorial and synergistic action of specific DNA-binding activators and repressors on components of the general transcription machinery and chromatin...
My research focuses on understanding the relationship between genotype and phenotype, with a special interest in how biochemistry, molecular design, and wiring can allow cells to process information from their environment and respond appropriately. By...
Why do we grow old? Why does aging cause disease? Can we slow aging or even reverse it? These are some of the greatest unsolved questions in biology. Advances in technology are allowing us to probe these questions more deeply and more rapidly than ever...
We seek to use the vast knowledge of biology to predictably design biological systems to enhance our fundamental understanding and to provide solutions for real world problems.
Current projects use mammalian cells, simple eukaryotes and prokaryotes....
We are interested in the molecular mechanisms by which proteins are transported across the endoplasmic reticulum (ER) membrane. Proteins are transported through a protein-conducting channel, formed from a conserved trimeric membrane protein complex...
Our laboratory aims to understand normal cell division mechanisms and to discover cell division defects that are unique to cancer cells. We take a range of approaches including genetics, functional genomics, biochemistry and live cell imaging. There are...
The vertebrate immune system is capable of specifically recognizing and responding to an enormous number of antigens. The interaction with antigen is mediated by the immunoglobulin (Ig) and T cell receptor (TCR) molecules expressed by B and T lymphocytes...
Mitochondria are tiny organelles found in nearly all cells, serving as the center stage for ATP production, ion homeostasis, and apoptosis. Their composition, density, and coupling efficiency are dynamic properties, varying across cell types and adapting...
