Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level theoretical conjectures about cellular networks have remained thin, largely because of lack of supporting experimental data.
To address how complex cellular networks relate to biology, we undertake, at the scale of the whole proteome, integrated approaches for mapping protein-protein interaction or "interactome" networks. The questions we face are: How are interactome networks organized at the scale of the whole cell? How can local and global features underlying this organization be uncovered? How are interactome networks disrupted in human disease, such as cancer?
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