The Gibson Lab uses tools from chemical biology to develop novel therapeutic platforms with the potential to profoundly impact cancer treatment. We are especially focused on addressing areas traditionally considered "undruggable," such as tumor suppressor...
The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
Our group studies patterns of rare genetic variation in large collections of human genomic data, both from patients and reference population individuals, and designs tools and methods to help interpret that variation. We are focused on moving from...
Gene expression control is fundamental to all biological systems and is primarily mediated by transcription factors (TFs) that bind specific DNA sequences. This control is quantitative—approximately 50% reductions in TF levels cause rare disorders, while...
The Tsvetkov Lab investigates how metal homeostasis and metabolic regulation intersect to control cell fate, with a particular focus on copper biology and mitochondrial metabolism. We combine high-throughput chemical-genomic approaches with molecular and...
The research in our lab focuses on tissue-responsive nanomaterials for biomedical applications and is dedicated to leveraging materials science and engineering, imaging and basic science to improve human health. We develop smart material platforms that...
My laboratory is interested in the molecular mechanisms of DNA repair pathways that ensure genome stability and suppress tumorigenesis. We are especially interested in the homologous recombination (HR), which is an essential pathway for the repair of DNA...
The Gupta Lab studies the gene regulatory networks that cause vascular disease using high-throughput CRISPR screens. We have expanded Perturb-seq methods to cover all 20,000 genes and identified co-regulated gene networks using AI/ML methods. For coronary...
The Mancias Lab, located at the Dana-Farber Cancer Institute is focused on the study of pancreatic ductal adenocarcinoma (PDAC). PDAC is one of the most vexing problems in cancer with 5-year overall survival rates of 13%, thus there is a strong need for...
The Tsai Laboratory studies transcription factor protein stability and developing new methods to target transcription factors for degradation to treat disease. Many proteins are removed through ubiquitination and proteasomal degradation; recent studies...
