We are interested in defining the molecular pathways that during development of the mammalian cerebral cortex direct the differentiation of neural progenitors/stem cells into distinct types of projection neurons, and the establishment of their...
There is now overwhelming evidence indicating that VEGF, TGFβ, PDGF, and Notch among others, the molecules that are essential for vascular formation, are also part of the cell signaling circuitry contributing to vessel maintenance and the cellular...
Messenger RNA is in constant flux between different locations and states -- the nucleus and cytoplasm, activation and silencing, translation and decay. Classical nuclear bodies such as nucleoli and nuclear speckles are self-generated RNA structures whose...
Our laboratory at Dana-Farber Cancer Institute is a basic and translational oncology laboratory focused on studying pancreatic cancer and other RAS-driven malignancies. We utilize genomic, functional genetic, molecular and cell biology approaches to...
We are interested in elucidating the mechanisms controlling immune privilege of tissue-resident stem cells and cancer stem cells.
Stem cells are crucial for tissue homeostasis and regeneration and, as a consequence, some have evolved mechanisms to cloak...
The Aguayo-Mazzucato Lab is interested in studying the aging process of pancreatic beta cells and how it contributes to the development of diabetes. Additionally, we are interested in identifying pharmacological and non-pharmacological senolytic...
Certain genetic disorders cause widespread disease in the body, but the principle reason for illness and death in early childhood is failure of the blood system. We would like to study these genetic blood disorders by “turning back the clock” – using new...
The Adelman lab aims to elucidate how cells react in a rapid yet balanced manner to external signals, at the transcriptional and epigenetic level. We use a combination of genomics, genetics and biochemistry to study the dynamics of gene expression, with a...
I am the director of urology research at Boston Children's Hospital and a cell biologist and biochemist by training. Research in my laboratory focuses on studies investigating the molecular basis of hollow organ pathobiology, with a focus on tissue...
We use methods in molecular biology, immunology, and structural biology to study host-pathogen interactions, with the goal of informing strategies aimed at treating or preventing infection.
Several enveloped RNA viruses cause human viral hemorrhagic fevers...
