The van Opijnen Lab works at the intersection of microbial systems biology, functional genomics, and computational modeling. Our central focus is understanding how bacterial pathogens survive the combined assault of host immunity and antibiotic treatment...
Small cell lung cancer (SCLC) is a highly aggressive and treatment-resistant malignancy with limited therapeutic options. This challenge stems in part from the near-universal loss-of-function (LOF) mutations in key tumor suppressor genes such as RB1 and...
The Jorfi Lab integrates neuroscience, immunology, and bioengineering to uncover how the immune system contributes to neurodegeneration, with a primary focus on Alzheimer’s disease and related disorders. Once thought to be immune-privileged, the brain is...
The Insco Lab investigates how aberrant RNA and defects in nuclear RNA surveillance drive oncogenesis, with an emphasis on melanoma. We use zebrafish models, patient datasets, and mechanistic assays in human melanoma cell lines to define clinically...
Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
The Horlbeck lab studies Chromatinopathies, a large class of genetic disorders in which disruption of chromatin modifying machinery leads to developmental delay and intellectual disability. The lab seeks to understand how chromatin regulation shapes cell...
The Walt lab pioneered the use of microwell arrays for ultra-sensitive biomarker detection and analysis, such as proteins and microRNAs. The technique, known as Single Molecule Arrays (Simoa), is based on digital enzyme-linked immunosorbent assay (ELISA)...
Our research will integrate organic chemistry, chemical biology, and cancer biology to develop covalent compounds that allow chemical rescue of somatic mutations in cancer currently deemed “undruggable”. Somatic mutations, particularly in proto-oncogenes...
The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
Our laboratory is focused on studying neuroblastoma, an embryonically derived pediatric tumor of the peripheral sympathetic nervous system. We are interested in the following general areas: 1) identifying molecular targets that can be translated into...
