The Walt lab pioneered the use of microwell arrays for ultra-sensitive biomarker detection and analysis, such as proteins and microRNAs. The technique, known as Single Molecule Arrays (Simoa), is based on digital enzyme-linked immunosorbent assay (ELISA)...
The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
Pathologists have observed alterations of nuclear structure for over a century. These morphologic nuclear changes are routinely used in cancer diagnostics, however the molecular underpinnings of these changes remain largely unknown. The Johnstone lab is...
We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to...
My laboratory uses genetic, molecular and cellular approaches to investigate critical roles of cell signaling in mammalian embryonic morphogenesis, and homeostatic maintenance of adult tissues, particularly in the skeleton, dental-craniofacial system and...
The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors. The lab began its studies on the signaling of a classical cytokine produced by the...
The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
Our laboratory studies molecular control of development and cell differentiation using self-renewing epithelia in the digestive tract as a model system.
The gastrointestinal tract is especially suited for molecular investigation of mechanisms that regulate...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
