The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
The Zhang lab is interested in how epigenetic modification-mediated dynamic changes in chromatin structure affects gene expression, stem cell reprogramming, germ cell development, beta-cell generation, and drug addiction. In the past decade, the lab has...
Our research is focused on the nature of highly aggressive, metastatic, late-stage cancers. We believe that such tumors differ markedly from less aggressive tumors and respond to different drugs than either primary tumors or dormant metastases...
Our laboratory studies how chromosome behavior and positioning influence genome function and evolution, with implications for gene regulation, genome stability, and diseases such as cancer and neurodevelopmental disorders. Using mammals, Drosophila, and...
Dr. Wu's laboratory focuses on dissecting the underlying mechanisms of pathobiology of chronic lymphocytic leukemia (CLL) as a means to more rationally generate effective therapies, including immune-based treatments, for this common adult leukemia. She...
Our lab studies signals that regulate the specification and maintenance of cell differentiation during early embryogenesis, tissue regeneration, and disease pathogenesis. We study embryogenesis and regeneration using frog embryos and tadpoles as a model...
Research in the Walker laboratory falls into two major areas. One is primarily directed towards addressing the problem of antibiotic resistance. We investigate bacterial pathways that may be targets for new antibiotics. We carry out detailed mechanistic...
The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause...
Within cells macromolecules form complex intertwined networks of functionally interacting components. The molecular mechanisms underlying biological processes correspond to particular steady states adopted by such cellular networks. Systems-level...
The primary goal of the research program in the Tothova laboratory is to contribute to our understanding of the biology of benign and malignant hematologic disorders, with a specific focus on the study of mechanisms of leukemogenesis in myelodysplastic...