Pamela A. Silver

Pamela A. Silver

Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology
Pamela A. Silver

What can we build with biology? We use a synthetic biology approach to understanding biological systems through design, making new biological structures with proteins and nucleic acids, new genetic networks, and new metabolic pathways with applications in basic science, medicine, and the environment. Our designs derive from what we learn from systems biological analyses. Current projects use mammalian cells, plants, simple eukaryotes and prokaryotes. Understanding how to program cells in a rational way will have value, for example, in stem cell design, drug therapy and the environment.

Some primary project areas include: Designing novel genetic pathways in mammalian cells, S. cerevisiae, and prokaryotes to probe basic cell biology, to better understand cancer initiation and progression, and to design potential diagnostics and therapeutics; and Engineering metabolism for sustainably by producing medicines, commodity chemicals, and fuels to understand and optimizing photosynthetic carbon fixation in cyanobacteria and plants and developing novel electrofuel producers. Other projects include organization of interactions within and between cells with novel scaffolds.

In sum, we seek to predictably design biology to address pressing issues in health and sustainability using state of the art technologies. Students have the opportunity to contribute to many active projects in these areas and to develop their own related ideas in an exciting environment.

Contact Information

Harvard Medical School
Warren Alpert Building, Room 420
200 Longwood Avenue
Boston, MA 02115
p: 617-432-6401

Community or Program Affiliation