The Insco Lab investigates how aberrant RNA and defects in nuclear RNA surveillance drive oncogenesis, with an emphasis on melanoma. We use zebrafish models, patient datasets, and mechanistic assays in human melanoma cell lines to define clinically...
Our laboratory is focused on studying neuroblastoma, an embryonically derived pediatric tumor of the peripheral sympathetic nervous system. We are interested in the following general areas: 1) identifying molecular targets that can be translated into...
Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The Langenau laboratory research focus is to uncover relapse mechanisms that enhance growth and tumor propagating cell frequency in pediatric cancer. Utilizing zebrafish models of T-cell acute lymphoblastic leukemia (T-ALL) and embryonal rhabdomysoarcoma...
The focus of this laboratory is to understand the genetic basis of development of form – that is shape, size and proportion during vertebrate development. We focus on the skeleton of the adult fish as a model to understand the genetic basis of growth and...
Lipid signaling in immunity and inflammatory disease
My laboratory studies the biology of the bioactive lipid mediator- sphingosine 1-phosphate (S1P), a fundamental regulator of immune and vascular systems. The vertebrate immune system co-evolved with the...
The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
My laboratory’s research focuses on the skeletal system. We employ a “bedside to bench to bedside” approach in order to delineate biologic pathways that are essential for skeletal health. Our research questions originate from patients with heritable...
Why do we grow old? Why does aging cause disease? Can we slow aging or even reverse it? These are some of the greatest unsolved questions in biology. Advances in technology are allowing us to probe these questions more deeply and more rapidly than ever...
