I am a computational biologist studying the role of chromatin structure/dynamics and non-coding regions including enhancers, promoters, insulators and their role in gene regulation. The mission of my lab is the integration of omics data to explore and...
Hematopoietic stem cells (HSCs) can give rise to each of the blood lineages present throughout a vertebrate’s lifetime. The gene programs and signaling networks regulating HSC development and function in the embryo and adult are highly evolutionarily...
Several long-term research projects in human genetics are ongoing in the Morton laboratory. An overall theme is to apply evolving techniques in molecular cytogenetics to address problems in human cytogenetics; our interests include chromosomal...
The Megason Lab uses imaging-based systems biology to elucidate the systems level principles of animal development. We are particularly interested in long standing problems in embryology whose understanding has defied molecular reduction namely patterning...
The muscular dystrophies are progressive disorders of striated muscle leading to breakdown of muscle integrity. There is considerable clinical variability in the muscular dystrophies with the most common form caused by abnormalities of dystrophin and the...
The increasing emergence of bacterial strains resistant to antibiotics is far outpacing our ability to develop novel therapies to treat these infections. Further, the methodologies used to both diagnose infection and predict appropriate courses of...
CHEMICAL GENOMICS OF NEUROPSYCHIATRIC DISORDERS
The long-term goal of the Haggarty laboratory is to advance the discovery of novel targets and therapeutic agents for the treatment of cognitive and mood disorders using translational neurobiology and the...
Our laboratory is using cellular, molecular, bioengineering, and computational biology tools to understand how mechanical forces generated by the flow of blood act on blood vessels to activate signaling pathways critical for cellular specification during...
Research in our laboratory is committed to expanding our molecular understanding of the formation and regeneration of tendons and ligaments. Injuries to tendons and ligaments result in a slow and imperfect regenerative response. In most cases, the...
Our research focuses on both developmental biology and translational medicine, and involves the use of pluripotent stem cells to understand how musculoskeletal lineages, primarily articular chondrocytes and cartilage tissues, are specified during...
