The research efforts in the laboratory are directed towards understanding the molecular basis of pathogenesis of human infections caused by opportunistic...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic... Read more about John Mekalanos
in situ single-cell transcriptomic techniques offer the exciting ability to characterize gene expression within single cells in their native tissue context.... Read more about Jeffrey Moffitt
We are interested in mechanisms whereby bacterial pathogens cause disease and in defining and testing immune protective mechanisms relevant to prevention...
Despite the growing recognition of the importance of the microbiota to humans, there are fundamental aspects of the microbiota and its relation to the...
Adjunct Professor of Immunology and Infectious Diseases
Despite years of research, tuberculosis remains a leading killer, causing almost two million deaths each year worldwide. While the treatment for drug-...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the...
Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology
We seek to use the vast knowledge of biology to predictably design biological systems to enhance our fundamental understanding and to provide solutions...
Why do we grow old? Why does aging cause disease? Can we slow aging or even reverse it? These are some of the greatest unsolved questions in biology....
My research focuses on understanding the relationship between genotype and phenotype, with a special interest in how biochemistry, molecular design, and...
Research in our lab uses a combination of cellular and molecular approaches in the analysis of T-cell responses to bacterial pathogens. Many virulence...
Our lab is broadly interested in the biology of immune proteins found throughout nature. Bacteria have evolved numerous defenses against phage, including...
David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
Transcriptional regulation in response to environmental and developmental cues is mediated by the combinatorial and synergistic action of specific DNA-...
We study immune signaling pathways to understand the role of innate immune cells in liver diseases. Our studies focus on molecular mechanisms of inflammation... Read more about Gyongyi Szabo