Tissue Immune Regulation
The successful immune response is designed to cope with tissue malfunction or infection and is self-limiting in nature. Immune cells may exert a broad spectrum of context-dependent immune responses in a highly flexible manner, where an individual cell may shift between low/high activation state or polarized towards unique proinflammatory or immunosuppressive functional states. Central to the regulation of immune cells are non-immune cells such as epithelial cells and fibroblasts, which cooperate within tissues to shape the immune response in health and disease. Our lab studies these cellular circuits within tissues as an important axis that determines the ability to establish tolerance, mount an effective response against pathogens, or drive chronic inflammation. We aim to leverage new mechanisms of tissue immune regulation to better understand the pathogenesis of inflammatory disorders such as colitis, sepsis and multiple sclerosis.
Building for Transformative Medicine, Room 9016AA
60 Fenwood Road
Boston, MA 02115