Myles Brown

Myles Brown

Emil Frei III Professor of Medicine
Myles Brown
The primarily focus of the work in my laboratory is the molecular understanding of the action of steroid hormone receptors and their role in human cancer. We were the first to identify the p160 class of steroid receptor coactivators and to show that coregulators play an important role in the tissue and promoter selective action of steroid hormone receptors and their ligands. My lab was the first to define steroid receptor binding sites on a genome-wide scale. This led to the concept of the cistrome, the set of cis-acting targets of a trans-acting factor across the genome. Most recently we have used ChIP-seq to define the epigenomic and cistromic changes that underlie the development of hormone independent cancer. Together with Shirley Liu I direct the Center for Functional Cancer Epigenetics at the Dana-Farber. The experimental platforms and computational expertise of the center is available to support the work of the trainees in my lab.

Contact Information

Dana-Farber Cancer Institute
Dana Building, Room D730
450 Brookline Ave.
Boston, MA 02115
p: 617-632-3948

Community or Program Affiliation