The Camargo Lab is focused on understanding how stem cells build, maintain, and repair tissues, and how these processes go awry in disease. We develop and apply cutting-edge technologies that allow us to study cell fate decisions in their native...
Though much of what defines a human is encoded in the sequence of our DNA, many additional factors influence how this genetic information is manifest. For example, heritable epigenetic information contained within chromatin, the higher-order structure...
The primary focus of the work in my laboratory is the molecular understanding of the action of steroid hormone receptors and their role in human cancer. We were the first to identify the p160 class of steroid receptor coactivators and to show that...
The broad focus of the Alt lab is the elucidation of mechanisms that generate antigen receptor diversity in the Immune system and mechanisms that maintain genomic stability in mammalian cells. Over the past decade we have developed remarkably sensitive...
Most of our genome is highly repetitive sequence derived from the activities of selfpropagating retrotransposons. Research in the Burns lab focuses on roles these mobile genetic elements play in human disease. Despite their enormous impact on genome...
The Ubellacker Lab leverages metabolic vulnerabilities in metastasizing cells to target and treat cancer, with a focus on exploiting lipidomic dependencies of cancer cells. We are working to discover mechanisms that explain how lipid availability in the...
Brain tumors are the leading cause of cancer related death in childhood. Children that do survive are frequently left with life-long and devastating morbidities that arise from the tumors, and the treatments required to cure them. Our lab applies genomic...
Over the past decade, the treatment of lung cancer has been dramatically transformed by the development of molecular targeted therapies and immunotherapies that are enabling increasingly personalized treatment regimens. While this has led to significant...
The laboratory focuses on the developmental biology of hematopoiesis and cancer. We have collected over 30 mutants affecting the hematopoietic system. Some of the mutants represent excellent animal models of human disease. We also have undertaken...
Apoptosis is a prevalent and important cell fate during development and homeostasis of multicellular organisms. The long-term goal of our research is to understand the regulation and execution of apoptosis, using the powerful genetic and molecular...
