Most of our genome is highly repetitive sequence derived from the activities of selfpropagating retrotransposons. Research in the Burns lab focuses on roles these mobile genetic elements play in human disease. Despite their enormous impact on genome...
The Insco Lab investigates how aberrant RNA and defects in nuclear RNA surveillance drive oncogenesis, with an emphasis on melanoma. We use zebrafish models, patient datasets, and mechanistic assays in human melanoma cell lines to define clinically...
The Ebert laboratory focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS). In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that...
Our laboratory studies the role of cell cycle machinery in normal cell proliferation and in oncogenesis using mouse genetic, genomic, proteomic and systems biology approaches.
Cyclins and their catalytic partners, cyclin-dependent kinases (CDKs) are...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
My laboratory is focused on two tumor suppressor gene diseases associated with renal tumorigenesis and hamartomas: tuberous sclerosis complex (TSC) and Birt-Hogg-Dube (BHD) syndrome. I have a particular interest in lymphangioleiomyomatosis (LAM), which is...
Our laboratory is using cellular, molecular, bioengineering, and computational biology tools to understand how mechanical forces generated by the flow of blood act on blood vessels to activate signaling pathways critical for cellular specification during...
Research in the Levy Lab focuses on endogenous mechanisms for resolution of lung inflammation and injury. The laboratory's overall mission is to identify natural small molecule regulators of the severity and duration of innate and adaptive immune...
Though much of what defines a human is encoded in the sequence of our DNA, many additional factors influence how this genetic information is manifest. For example, heritable epigenetic information contained within chromatin, the higher-order structure...
The overall goal of our research is to understand the role of the tumor microenvironment, including the tumor vasculature and matrix, in tumor growth and response to therapy, to develop novel strategies to manipulate the tumor microenvironment, and to...
My laboratory is interested in how microenvironmental cues, particularly mechanical forces and extracellular matrix, regulate tissue development, physiology and pathology. Our work covers a wide range from fundamental studies of the molecular basis of...
Our laboratory is interested in the biochemistry and molecular and cell biology of neuronal degeneration during aging of the mammalian brain, particularly in Alzheimer's (AD) and Parkinson's (PD) diseases. The laboratory originally developed methods for...
