The lab is interested in the ubiquitin-proteasome pathway. There are several ongoing projects:
Usp14 is a proteasome-associated deubiquitinating enzyme. We study both the mammalian (USP14) and yeast (Ubp6) forms of the enzyme. USP14/Ubp6 is a powerful...
The goal of my lab is to understand the regulatory relationship between cellular signaling pathways and metabolic pathways. We are particularly interested in the PI3K (phosphoinositide-3-kinase) signaling pathway which is a major regulator of glucose and...
Cancer cells display remarkable plasticity allowing them to adapt to ever changing environments. A key feature of this plasticity is their ability to rewire core metabolic networks to provide a steady source of energy and building blocks needed for rapid...
The Aguayo-Mazzucato Lab is interested in studying the aging process of pancreatic beta cells and how it contributes to the development of diabetes. Additionally, we are interested in identifying pharmacological and non-pharmacological senolytic...
