The Jorfi Lab integrates neuroscience, immunology, and bioengineering to uncover how the immune system contributes to neurodegeneration, with a primary focus on Alzheimer’s disease and related disorders. Once thought to be immune-privileged, the brain is...
The Tsvetkov Lab investigates how metal homeostasis and metabolic regulation intersect to control cell fate, with a particular focus on copper biology and mitochondrial metabolism. We combine high-throughput chemical-genomic approaches with molecular and...
The Mancias Lab, located at the Dana-Farber Cancer Institute is focused on the study of pancreatic ductal adenocarcinoma (PDAC). PDAC is one of the most vexing problems in cancer with 5-year overall survival rates of 13%, thus there is a strong need for...
Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
Research in the Wolfson lab is focused on understanding how we sense our internal environment. Sensory neurons that innervate internal organs have cell bodies that reside in the dorsal root ganglia, the DRG sensory neurons. These neurons must respond to a...
The overall theme of our lab is the regulation of energy homeostasis in mammalian systems, with special reference to adipose and muscle tissues. While we have long been interested in diabetes and obesity, our current interests extend to muscle disorders...
We are interested in the mechanisms by which cells regulate their gene expression patterns stably and heritably. Stable inheritance of distinct transcriptional states that persist through numerous cell divisions is critical for the formation of cellular...
The vast array of forms and functions exhibited by different cell types is made possible by the organization of specialized domains within the cell cortex. The overarching goal of our laboratory is to understand how the organization of protein complexes...
Internal and external senses
We study internal sensory systems using molecular and genetic approaches. The vagus nerve is an essential body-brain communication axis that controls vital functions of the respiratory, cardiovascular, digestive, and immune...
How nutrient uptake and utilization is altered in cancer, how the host systemic metabolic state can influence these alterations and in turn, get affected by tumor growth and metabolism, are major focus areas in our lab.
Altered metabolism is a hallmark of...
