The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive...
Our lab has two main interests: 1) Understanding the mechanisms involved in cell-cell signaling through the vertebrate Hedgehog pathway; and 2) Synthesizing and validating new chemical probes for microscopic imaging and functional assays of various...
We are interested in the molecular mechanisms by which proteins are transported across the endoplasmic reticulum (ER) membrane. Proteins are transported through a protein-conducting channel, formed from a conserved trimeric membrane protein complex...
Our lab investigates broad aspects of fundamental metabolic and energetic processes in mammals that are necessary for cell survival and specific biological function. We combine and apply a variety of biochemical, cellular, genetic, chemical biology...
Our laboratory aims to understand normal cell division mechanisms and to discover cell division defects that are unique to cancer cells. We take a range of approaches including genetics, functional genomics, biochemistry and live cell imaging. There are...
Research Activities
My laboratory studies skeletal and vascular development, growth and remodeling/repair. Work is currently directed at three projects.
In the first project we investigate mechanisms that control the development and homeostasis of the...
Our laboratory researches how cancer cells develop drug resistance, and more specifically, how the tumor microenvironment provides support and protection to tumor cells. Results from these studies will allow us to develop better strategies to overcome...
Cells need to accurately maintain their nuclear DNA in order to function properly. Indeed, defects in DNA integrity are associated with cancer, aging, and immunodeficiency. Therefore, numerous DNA repair systems in mammalian cells function to endow us...
We are interested in epigenetic mechanisms that control cellular memory and genome stability in eukaryotes and use yeast and mammalian cells as model systems to study these mechanisms.
We study how heterochromatin, a silent chromatin structure that...
Recurrence of cancer in the form of metastatic disease accounts for more than 90% of cancer patient deaths; however, tumor metastasis is considered an inefficient process and disseminated tumor cells can remain indolent for long periods of time...
