We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a focus on the role of mechanical force. More specifically, we investigate how force regulates the structure and dynamics of interactions between...
Research in the Walker laboratory falls into two major areas. One is primarily directed towards addressing the problem of antibiotic resistance. We investigate bacterial pathways that may be targets for new antibiotics. We carry out detailed mechanistic...
For a living cell to function properly, its cellular processes must be strictly controlled not only in time but also in space. We are interested in how intracellular spatial organization on the micron-length scale is achieved by nanometer-sized proteins...
We work on receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and...
Structural Biology and Computing provide robust tools to dissect mechanisms of disease.
To fully elucidate reaction mechanisms, develop effective functional probes, or rationalize searches for small molecule inhibitors, one usually needs to determine the...
The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive...
Research in the Ruvkun lab has explored three major themes: microRNA genes and other small RNAs, control of longevity and immune surveillance, and detection of life on other planets. We discovered in collaboration with Victor Ambros in 1992 that the...
We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and genomic approaches to study patterning and differentiation of the precursors of muscles...
Physiological and Regenerative Homeostasis in Drosophila
The central objective of developmental biology is to understand how organisms grow to adulthood. In the past 30 years, studies using genetically tractable model systems have led to a detailed...
Our laboratory aims to understand normal cell division mechanisms and to discover cell division defects that are unique to cancer cells. We take a range of approaches including genetics, functional genomics, biochemistry and live cell imaging. There are...
