Our research explores how we learn from our mistakes—a fundamental building block of intelligent behavior. As infants learning to walk, we take unsteady steps, fall, adjust, and eventually develop stable locomotion. This iterative cycle of action, error...
Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors. The lab began its studies on the signaling of a classical cytokine produced by the...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
William Shih is a Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Institute and a Founding Core Faculty member at the Wyss Institute...
Our current research includes three themes. First, we are studying the role of non-canonical nucleic acid structures, G-quadruplex (G4) and R-loop in gene expression, both at the level of transcription and translation in e.coli and mammalian cells. G4 is...
Our lab is focused on development and application of proteomics-based methods for in-depth analysis of key molecular events in tumorogenesis. Given the highly dynamic nature of biological processes, we are particularly interested in novel and robust...
My research program focuses on studying mRNA translation in parasites that significantly burden global health, including Leishmania, Babesia, and Plasmodium organisms.
Our efforts notably center on characterizing translation initiation factors and...
The overall goal of our research is to understand the role of the tumor microenvironment, including the tumor vasculature and matrix, in tumor growth and response to therapy, to develop novel strategies to manipulate the tumor microenvironment, and to...
Our laboratory studies how blood platelets, which function as the bandaids of the bloodstream, are produced from megakaryocyte precursor cells. Megakaryocytes are terminally differentiated cells that in their final hours convert into long, branched...
