The van Opijnen Lab works at the intersection of microbial systems biology, functional genomics, and computational modeling. Our central focus is understanding how bacterial pathogens survive the combined assault of host immunity and antibiotic treatment...
Small cell lung cancer (SCLC) is a highly aggressive and treatment-resistant malignancy with limited therapeutic options. This challenge stems in part from the near-universal loss-of-function (LOF) mutations in key tumor suppressor genes such as RB1 and...
Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
The Horlbeck lab studies Chromatinopathies, a large class of genetic disorders in which disruption of chromatin modifying machinery leads to developmental delay and intellectual disability. The lab seeks to understand how chromatin regulation shapes cell...
Our group studies patterns of rare genetic variation in large collections of human genomic data, both from patients and reference population individuals, and designs tools and methods to help interpret that variation. We are focused on moving from...
Gene expression control is fundamental to all biological systems and is primarily mediated by transcription factors (TFs) that bind specific DNA sequences. This control is quantitative—approximately 50% reductions in TF levels cause rare disorders, while...
The Tsai Laboratory studies transcription factor protein stability and developing new methods to target transcription factors for degradation to treat disease. Many proteins are removed through ubiquitination and proteasomal degradation; recent studies...
We study how Epstein-Barr virus causes nearly 1% of all human cancers and also serves as the major viral trigger for autoimmune diseases, in particular multiple sclerosis.
A fascinating and incompletely understood aspect of EBV pathogenesis is that it...
Pathologists have observed alterations of nuclear structure for over a century. These morphologic nuclear changes are routinely used in cancer diagnostics, however the molecular underpinnings of these changes remain largely unknown. The Johnstone lab is...
We are interested in the fundamental mechanisms of neurodegenerative disorders like Alzheimer’s disease. Over the past century-plus, research has revealed specific proteins that misfold and are deposited in neurodegeneration, and recent discoveries have...
