The Segel lab is interested in the evolution of mammalian lifespan. From single cells to whole organisms, we are interested in the molecular pathways that govern the pacing of postnatal mammalian development.
We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to...
My lab works at the intersection of virology, immunology and systems biology. Our core mission is to uncover global principles in virology by decoding hundreds of viral genomes. Our projects revolve around a central question: how have the compact genomes...
Genomics of human disease. We are interested in the functional consequences of the complete spectrum of genomic variation on human disease, with a particular focus on congenital birth defects, autism, neurodevelopmental disorders, and diverse...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
Our laboratory studies molecular control of development and cell differentiation using self-renewing epithelia in the digestive tract as a model system.
The gastrointestinal tract is especially suited for molecular investigation of mechanisms that regulate...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
The Mekalanos laboratory is engaged in the analysis of bacterial virulence and functional genomics. The goal of these studies is to understand how pathogenic bacteria grow, evade the host immune system and ultimately cause disease. A variety of organisms...
Our lab is focused on development and application of proteomics-based methods for in-depth analysis of key molecular events in tumorogenesis. Given the highly dynamic nature of biological processes, we are particularly interested in novel and robust...
The research efforts in the laboratory are directed towards understanding the molecular basis of pathogenesis of human infections caused by opportunistic gram-negative bacteria. We have used Pseudomonas aeruginosa as a model opportunistic pathogen...
