My lab works at the intersection of virology, immunology and systems biology. Our core mission is to uncover global principles in virology by decoding hundreds of viral genomes. Our projects revolve around a central question: how have the compact genomes...
Our laboratory pursues both basic and translational studies to understand and treat infections caused by intestinal bacteria. Areas of interest described below include the impact of intestinal pathogens on host metabolism and nutrition, development of...
The overall theme of our lab is the regulation of energy homeostasis in mammalian systems, with special reference to adipose and muscle tissues. While we have long been interested in diabetes and obesity, our current interests extend to muscle disorders...
Our laboratory studies molecular control of development and cell differentiation using self-renewing epithelia in the digestive tract as a model system.
The gastrointestinal tract is especially suited for molecular investigation of mechanisms that regulate...
The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...
We study the relationships between mammalian double strand break (DSB) repair, genomic instability and cancer. Two major pathways contribute to DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). Each plays a key role in...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The Rashidian Lab studies cancer immunology and autoimmune disease using expertise in molecular biology, chemical biology and immunology.
Molecule analysis of blood cell development has served as an important paradigm for stem cell biology. We have obtained a solid foundation in understanding how commitment to specific lineages is programmed and cell-specific patterns of gene expression are...
Our current research includes three themes. First, we are studying the role of non-canonical nucleic acid structures, G-quadruplex (G4) and R-loop in gene expression, both at the level of transcription and translation in e.coli and mammalian cells. G4 is...
