Cancer cells display remarkable plasticity allowing them to adapt to ever changing environments. A key feature of this plasticity is their ability to rewire core metabolic networks to provide a steady source of energy and building blocks needed for rapid...
My laboratory employs approaches rooted in synthetic immunology as a means of engineering or enhancing the natural immune system with the goal of understanding, preventing and treating HIV infection. We are currently applying these approaches to a number...
Protein-Protein Interactions (PPIs) is the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted with high specificity. Arthanari lab uses structure-guided approaches to characterize and...
We are interested in defining the molecular pathways that during development of the mammalian cerebral cortex direct the differentiation of neural progenitors/stem cells into distinct types of projection neurons, and the establishment of their...
There is now overwhelming evidence indicating that VEGF, TGFβ, PDGF, and Notch among others, the molecules that are essential for vascular formation, are also part of the cell signaling circuitry contributing to vessel maintenance and the cellular...
Our laboratory at Dana-Farber Cancer Institute is a basic and translational oncology laboratory focused on studying pancreatic cancer and other RAS-driven malignancies. We utilize genomic, functional genetic, molecular and cell biology approaches to...
The Adelman lab aims to elucidate how cells react in a rapid yet balanced manner to external signals, at the transcriptional and epigenetic level. We use a combination of genomics, genetics and biochemistry to study the dynamics of gene expression, with a...
We use methods in molecular biology, immunology, and structural biology to study host-pathogen interactions, with the goal of informing strategies aimed at treating or preventing infection.
Several enveloped RNA viruses cause human viral hemorrhagic fevers...
