Faculty

Aaron Hata

ahata@mgh.harvard.edu

Assistant Professor

Over the past decade, the treatment of lung cancer has been dramatically transformed by the development of molecular targeted therapies and immunotherapies that are enabling increasingly personalized treatment regimens. While this has led to significant...

Aaron Schmidt

aaron_schmidt@hms.harvard.edu

Associate Professor of Microbiology

Title: Using protein engineering, antibody evolution and small-molecule discovery to dissect host-pathogen interactions Key words: Protein engineering, viral evolution, host-pathogen interactions, small-molecule discovery Our research focuses on the...

Adrian Salic

adrian_salic@hms.harvard.edu

Professor of Cell Biology

Our lab has two main interests: 1) Understanding the mechanisms involved in cell-cell signaling through the vertebrate Hedgehog pathway; and 2) Synthesizing and validating new chemical probes for microscopic imaging and functional assays of various...

Alan B. Cantor

alan.cantor@childrens.harvard.edu

Associate Professor of Pediatrics

Hematopoiesis serves as a useful model system for studies of cell fate determination and lineage plasticity. Lineage-specific transcription factors play essential roles in these processes by activating terminal maturation genes, while simultaneously...

Alan Brown

Alan_Brown@hms.harvard.edu

Associate Professor of Biological Chemistry and Molecular Pharmacology

We are interested in understanding transport mechanisms in the cell. In particular, we are interested in how molecules are transported into, out of, and within cilia. Cilia (also known as flagella) are finger-like organelles that project from the surface...

Alan David D'Andrea

alan_dandrea@dfci.harvard.edu

Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology

Our laboratory examines the molecular signaling pathways which regulate the DNA damage response in mammalian cells. Disruption of these pathways, by germline or somatic mutation, leads to genomic instability, cellular sensitivity to ionizing radiation...

Alejandro Benjamin Balazs

abalazs@mgh.harvard.edu

Associate Professor of Medicine

My laboratory employs approaches rooted in synthetic immunology as a means of engineering or enhancing the natural immune system with the goal of understanding, preventing and treating HIV infection. We are currently applying these approaches to a number...

Aleksandar Kostic

Aleksandar.Kostic@joslin.harvard.edu

Assistant Professor of Microbiology

My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1 diabetes. As a 2013 BBS grad, I understand what it takes to have a successful Ph.D. experience. The...

Alex Toker

atoker@bidmc.harvard.edu

Professor of Pathology

The major focus of our laboratory is to investigate the cell and molecular biology of cancer, with a focus on the PI 3-Kinase and AKT signaling pathway in cancer. We have investigated the regulation and function of the Akt/PKB and SGK protein kinases...

Alexander Soukas

asoukas@mgh.harvard.edu

Assistant Professor of Medicine

Diabetes and Obesity Genetics. The Soukas Laboratory in the Center for Human Genetic Research and the Diabetes Unit at the MGH seeks to understand the pathogenesis of obesity and diabetes, and to identify new therapeutic targets for these common...

Allegra Petti

apetti@mgh.harvard.edu

Assistant Professor

My lab studies the development and evolution of cancer through analysis of intratumoral genetic, transcriptional, and immunological heterogeneity. Our work lies at the intersection of computational biology, molecular biology, and medicine: Using...

Amy Barczak

abarczak@mgh.harvard.edu

Assistant Professor of Medicine

Work in the Barczak lab focuses on the molecular pathogenesis of Mycobacterium tuberculosis. After COVID-19, tuberculosis is the leading cause of death from infection globally. A comprehensive understanding of the cellular and molecular events that drive...

Amy Lee

Alee13@partners.org

Assistant Professor

How do cells sharing the same DNA produce drastically distinct phenotypes? In one organism, the same genome allows for the development of different tissues, controlled cell cycle progression, and specialized responses to environmental stimuli. This occurs...

Amy Wagers

amy_wagers@harvard.edu

Forst Family Professor of Stem Cell and Regenerative Biology

The broad interest of the WAGERS LAB is to identify and analyze tissue-specific stem cell populations in adult animals. This work focuses on understanding the factors controlling the migration and expansion of bone marrow-derived and blood-forming...

Andi McClatchey

mcclatch@helix.mgh.harvard.edu

Professor of Pathology

The vast array of forms and functions exhibited by different cell types is made possible by the organization of specialized domains within the cell cortex. The overarching goal of our laboratory is to understand how the organization of protein complexes...

Andrew Aguirre

andrew_aguirre@dfci.harvard.edu

Assistant Professor of Medicine

Our laboratory at Dana-Farber Cancer Institute is a basic and translational oncology laboratory focused on studying pancreatic cancer and other RAS-driven malignancies. We utilize genomic, functional genetic, molecular and cell biology approaches to...

Andrew B. Lassar

andrew_lassar@hms.harvard.edu

Professor of Biological Chemistry and Molecular Pharmacology

The overarching goal of the Lassar lab is to understand how different cells types (i.e., articular or epiphyseal chondrocytes, ligaments and synoviocytes) emerge from a common precursor population during the formation of the synovial joint. Towards this...

Andrew Kruse

Andrew_Kruse@hms.harvard.edu

Professor of Biological Chemistry and Molecular Pharmacology

Signal transduction across cell membranes plays a central role in human physiology and disease, yet the mechanistic details underlying transmembrane signaling remain poorly understood. Our research aims to elucidate the molecular basis of membrane protein...

Ann Hochschild

ahochschild@hms.harvard.edu

Maude and Lillian Presley Professor of Microbiology

Our laboratory uses bacteria to study fundamental mechanisms of transcription regulation, as well as the biology of prions. With an emphasis on the development of genetic tools, our work also encompasses biochemical, structural and microscopy-based...

Anna Greka

agreka@bwh.harvard.edu

Professor of Medicine

The mission of the Greka laboratory is to define fundamental aspects of membrane protein biology and dissect mechanisms of cellular homeostasis. The laboratory complements this cell biology-focused program with tools from molecular biology, genomics...

Anne O'Donnell-Luria

anne.odonnell@childrens.harvard.edu

Assistant Professor

The O’Donnell-Luria laboratory studies how genetic variation contributes to the development of rare disease in humans. While individually rare, these conditions collectively affect ~5% of the population. Half of patients remain undiagnosed after clinical...

April M. Craft

april.craft@childrens.harvard.edu

Assistant Professor of Orthopedic Surgery

Our research focuses on both developmental biology and translational medicine, and involves the use of pluripotent stem cells to understand how musculoskeletal lineages, primarily articular chondrocytes and cartilage tissues, are specified during...

Arlene Sharpe

arlene_sharpe@hms.harvard.edu

Chair & Kolokotrones University Professor

The major interest of the Sharpe laboratory is to study functions of T cell costimulatory pathways and their immunoregulatory roles in controlling the balance between T cell activation and tolerance. Costimulation is of therapeutic interest because...

Benjamin Gewurz

bgewurz@bwh.harvard.edu

George and Sandra K. Schussel Associate Professor

We study how Epstein-Barr virus causes nearly 1% of all human cancers and also serves as the major viral trigger for autoimmune diseases, in particular multiple sclerosis. A fascinating and incompletely understood aspect of EBV pathogenesis is that it...

Benjamin L. Ebert

benjamin_ebert@dfci.harvard.edu

Richard and Susan Smith Professor of Medicine

The Ebert laboratory focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS). In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that...

Benjamin P. Kleinstiver

BKLEINSTIVER@mgh.harvard.edu

Associate Professor

The Kleinstiver group takes engineering-focused approaches to develop new genome engineering technologies for research applications and for the treatment of human diseases. They have synergistic efforts in the fields of genome editing technology...

Benjamin Stinson

benjamin_stinson@dfci.harvard.edu

Assistant Professor

My laboratory is interested in the molecular mechanisms of DNA repair pathways that ensure genome stability and suppress tumorigenesis. We are especially interested in the homologous recombination (HR), which is an essential pathway for the repair of DNA...

Bjorn R. Olsen

bjorn_olsen@hms.harvard.edu

Professor of Developmental Biology, Hersey Professor of Cell Biology

Research Activities My laboratory studies skeletal and vascular development, growth and remodeling/repair. Work is currently directed at three projects. In the first project we investigate mechanisms that control the development and homeostasis of the...

Bradley Bernstein

bernstein.bradley@mgh.harvard.edu

Professor of Cell Biology and Pathology

Though much of what defines a human is encoded in the sequence of our DNA, many additional factors influence how this genetic information is manifest. For example, heritable epigenetic information contained within chromatin, the higher-order structure...

Brian Seed

bseed@ccib.mgh.harvard.edu

Professor of Genetics

Work in our lab is centered on approaches to identify interesting genes and pathway connections using automated methods for analysis of function. We have amassed a collection of high efficiency expression plasmids that encompass a large fraction of the...