The overall goal of the Sethi lab is to combine clinical observations and patient-derived data with rigorous basic science investigation to yield opportunities for impactful translational advances. Our passion for investigative research is fundamentally...
During development, signaling pathways initiated by extracellular growth factors regulate and coordinate proliferation, differentiation, migration and survival. Understanding growth factor signaling pathways identifies critical steps in development and...
Research in the Roberts laboratory is centered on kinases, kinase inhibitors, and cancer. We work in a variety of model systems and utilize approaches varying from systems biology to mouse genetics. For instance, we have adapted telomerase immortalized...
The Rashidian Lab studies cancer immunology and autoimmune disease using expertise in molecular biology, chemical biology and immunology.
Our lab is focused on development and application of proteomics-based methods for in-depth analysis of key molecular events in tumorogenesis. Given the highly dynamic nature of biological processes, we are particularly interested in novel and robust...
The focus of my research is to understand mechanisms of sensitivity and resistance to kinase inhibitors and to translate laboratory based observations into therapeutic treatments for patients with cancer. To achieve this goal we have taken a multifaceted...
The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade...
We study cell signaling and regulation of the actin cytoskeleton using structural and biochemical approaches. We seek to understand fundamental signaling mechanisms and principles by dissecting out and determining the structure of “regulatory modules” –...
The focus of our laboratory is to decipher how metabolism of different carbon substrates (carbohydrates, fatty acids, amino acids and ketone bodies) modulates cellular stress responses. To this end, we employ a multi-disciplinary approach that draws on...
Our research focuses on deciphering the molecular mechanisms of metabolic disease and dysfunction, and using this information to develop targeted therapeutic strategies. Dysfunction in a particular cellular locale – the mitochondrion – is implicated most...
