The Cantley laboratory explores the biochemical mechanism by which alterations in protein and lipid kinases drive cancer growth and survival and the development of inhibitors of these pathways for treating cancer.
Our laboratory continues to focus on the molecular pathology and physiology of red cell development, the molecular basis of inherited hemolytic anemias, and the use of the red cell homeostatic system as a model to study gene regulation and growth control...
The primary focus of the work in my laboratory is the molecular understanding of the action of steroid hormone receptors and their role in human cancer. We were the first to identify the p160 class of steroid receptor coactivators and to show that...
The Raghavan Lab at Dana-Farber Cancer Institute and Harvard Medical School is a basic and translational oncology lab focused on understanding mechanisms of cell state regulation in cancer, evaluating how cell state plasticity influences therapeutic...
Most of our genome is highly repetitive sequence derived from the activities of selfpropagating retrotransposons. Research in the Burns lab focuses on roles these mobile genetic elements play in human disease. Despite their enormous impact on genome...
The BRCA1 tumor suppressor along with its protein binding partners is involved in a diverse array of DNA damage repair functions ranging from participation in repair of DNA double strand breaks to protection of stalled replication forks. Women with BRCA1...
Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens of de novo protein design. In de novo design, a protein’s...
We study the pathways that drive cancer initiation, progression, and drug resistance. We employ both genomic and functional genetic technologies to identify dysregulated pathways in cancer and explore how these can be targeted for therapeutic benefit. Our...
Brain tumors are the leading cause of cancer related death in childhood. Children that do survive are frequently left with life-long and devastating morbidities that arise from the tumors, and the treatments required to cure them. Our lab applies genomic...
The cell surface is a central hub of biological processes, transducing information from the cell’s surroundings to enable dynamic and specific responses to their local environment. Myriad human diseases result from the dysregulation of extracellular and...
