Repair of Double stranded DNA breaks-pathway choices and more
Double stranded DNA breaks (DSBs) are critical for cell health as a single unrepaired DSB is sufficient for inducing apoptosis. Two major mechanistically distinct pathways, homologous...
Dysregulation of protein homeostasis drives many types of cancer, infection and neurodegeneration. The ubiquitin system performs a central role in maintenance of proteostasis through reversible post-translational addition of (poly)ubiquitin to proteins, a...
Protein-Protein Interactions (PPIs) is the Holy Grail of therapeutic intervention, offering a plethora of distinct structural landscapes that can be targeted with high specificity. Arthanari lab uses structure-guided approaches to characterize and...
Our laboratory at Dana-Farber Cancer Institute is a basic and translational oncology laboratory focused on studying pancreatic cancer and other RAS-driven malignancies. We utilize genomic, functional genetic, molecular and cell biology approaches to...
We are interested in elucidating the mechanisms controlling immune privilege of tissue-resident stem cells and cancer stem cells.
Stem cells are crucial for tissue homeostasis and regeneration and, as a consequence, some have evolved mechanisms to cloak...
