The Jorfi Lab integrates neuroscience, immunology, and bioengineering to uncover how the immune system contributes to neurodegeneration, with a primary focus on Alzheimer’s disease and related disorders. Once thought to be immune-privileged, the brain is...
Our group studies patterns of rare genetic variation in large collections of human genomic data, both from patients and reference population individuals, and designs tools and methods to help interpret that variation. We are focused on moving from...
Our research explores how we learn from our mistakes—a fundamental building block of intelligent behavior. As infants learning to walk, we take unsteady steps, fall, adjust, and eventually develop stable locomotion. This iterative cycle of action, error...
Genomics of human disease. We are interested in the functional consequences of the complete spectrum of genomic variation on human disease, with a particular focus on congenital birth defects, autism, neurodevelopmental disorders, and diverse...
Title: Using protein engineering, antibody evolution and small-molecule discovery to dissect host-pathogen interactions
Key words: Protein engineering, viral evolution, host-pathogen interactions, small-molecule discovery
Our research focuses on the...
Our lab studies the development, function, and dysfunction of somatosensory and viscerosensory circuits that mediate our sense of touch and sensations from the gastrointestinal (GI) system, respectively. We are interested in how sensory experience...
We are interested in the mechanisms by which cells regulate their gene expression patterns stably and heritably. Stable inheritance of distinct transcriptional states that persist through numerous cell divisions is critical for the formation of cellular...
The vast array of forms and functions exhibited by different cell types is made possible by the organization of specialized domains within the cell cortex. The overarching goal of our laboratory is to understand how the organization of protein complexes...
The Langenau laboratory research focus is to uncover relapse mechanisms that enhance growth and tumor propagating cell frequency in pediatric cancer. Utilizing zebrafish models of T-cell acute lymphoblastic leukemia (T-ALL) and embryonal rhabdomysoarcoma...
The overall goal of our research is to understand the role of the tumor microenvironment, including the tumor vasculature and matrix, in tumor growth and response to therapy, to develop novel strategies to manipulate the tumor microenvironment, and to...
