The van Opijnen Lab works at the intersection of microbial systems biology, functional genomics, and computational modeling. Our central focus is understanding how bacterial pathogens survive the combined assault of host immunity and antibiotic treatment...
Small cell lung cancer (SCLC) is a highly aggressive and treatment-resistant malignancy with limited therapeutic options. This challenge stems in part from the near-universal loss-of-function (LOF) mutations in key tumor suppressor genes such as RB1 and...
The Jorfi Lab integrates neuroscience, immunology, and bioengineering to uncover how the immune system contributes to neurodegeneration, with a primary focus on Alzheimer’s disease and related disorders. Once thought to be immune-privileged, the brain is...
Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
Our research will integrate organic chemistry, chemical biology, and cancer biology to develop covalent compounds that allow chemical rescue of somatic mutations in cancer currently deemed “undruggable”. Somatic mutations, particularly in proto-oncogenes...
The Abudayyeh-Gootenberg lab is focused on the understanding and engineering of programmability in biology. These programmable systems, inspired by natural diversity, provide precise control over genomes, transcriptomes, and cellular identity, and are...
Our laboratory is focused on studying neuroblastoma, an embryonically derived pediatric tumor of the peripheral sympathetic nervous system. We are interested in the following general areas: 1) identifying molecular targets that can be translated into...
The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
Gene expression control is fundamental to all biological systems and is primarily mediated by transcription factors (TFs) that bind specific DNA sequences. This control is quantitative—approximately 50% reductions in TF levels cause rare disorders, while...
The Tsvetkov Lab investigates how metal homeostasis and metabolic regulation intersect to control cell fate, with a particular focus on copper biology and mitochondrial metabolism. We combine high-throughput chemical-genomic approaches with molecular and...
