Our laboratory studies the role of cell cycle machinery in normal cell proliferation and in oncogenesis using mouse genetic, genomic, proteomic and systems biology approaches.
Cyclins and their catalytic partners, cyclin-dependent kinases (CDKs) are...
Our lab focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem cells, and common mechanisms in reprogramming and cancer. Our subgroups study:
We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and genomic approaches to study patterning and differentiation of the precursors of muscles...
Our laboratory is interested in the intersection of normal hematopoietic development and blood diseases. Our research is rooted in the fundamental observation that adults and children are affected by different blood diseases. We believe that this is due...
Our laboratory studies diseases of the gastrointestinal tract, with emphasis on colorectal cancer (CRC) and inflammatory bowel disease (IBD). We use both conventional and systems biology approaches to integrate studies of genetically engineered mouse...
Adult mammalian hearts lack the ability to regenerate, and instead, respond to injury with maladaptive remodeling that leads to heart failure. In contrast, the newborn mouse heart can effectively regrow the damaged tissue. My lab will leverage single-cell...
The laboratory studies muscle stem cells in human and mouse tissues, with the goal of developing strategies that will slow the progression of and improve muscle function for muscular dystrophy. Skeletal muscle contains progenitors that express BMPR1a and...
The Gredler lab investigates how dynamic cellular behaviors generate complex tissue structures during vertebrate development. We focus on the developing mouse embryo as a model to understand how cells coordinate their behaviors in space and time to drive...
There are nearly two million Americans living with a limb amputation and even with the best modern surgical intervention, a human limb does not regenerate. Amazingly, however, the amputation of a child's fingertip can regenerate, and the medical...
We are interested in how kinases in general, and phosphatidylinositol 3-kinases (PI3K) in particular, control malignant transformation. The work of our laboratory integrates molecular biology, tissue engineering and novel mouse models of human cancer to...
The vast array of forms and functions exhibited by different cell types is made possible by the organization of specialized domains within the cell cortex. The overarching goal of our laboratory is to understand how the organization of protein complexes...
Why do we grow old? Why does aging cause disease? Can we slow aging or even reverse it? These are some of the greatest unsolved questions in biology. Advances in technology are allowing us to probe these questions more deeply and more rapidly than ever...
