Paul Joseph Anderson

Paul Joseph Anderson

K. Frank Austen Professor of Medicine
Paul Joseph Anderson
Messenger RNA is in constant flux between different locations and states -- the nucleus and cytoplasm, activation and silencing, translation and decay. Classical nuclear bodies such as nucleoli and nuclear speckles are self-generated RNA structures whose morphology and function are inextricably linked: altered morphology reflects altered function. Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) have been revealed as functional byproducts of mRNA metabolism. Stress granules (SGs) and processing bodies (PBs) share substrate mRNA, dynamic properties and many proteins, but also house separate components and independent functions. Each can exist without the other, but when coordinately induced they are often tethered together in a cytosolic dance. Work in the laboratory is focused on understanding the role of subcellular localization in the control of mRNA translation/decay.

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Brigham and Women's Hospital
Building for Transformative Medicine, 5th Floor
60 Fenwood Road
Boston, MA 02115
p: 617-525-1202

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