The Chao Lab seeks to understand the molecular mechanisms underlying membrane shape. We apply an approach integrating structural biology, biophysics, bioinformatics and physiology, to investigate membrane remodeling and ultrastructure in mitochondria and...
Lipid signaling in immunity and inflammatory disease
My laboratory studies the biology of the bioactive lipid mediator- sphingosine 1-phosphate (S1P), a fundamental regulator of immune and vascular systems. The vertebrate immune system co-evolved with the...
The Rogers lab works to identify new targets and therapeutics for angiogenesis-dependent disease. A key element of this work is our efforts to understand the role of Capillary Morphogenesis Gene 2 (CMG2) in angiogenesis and the signaling pathway...
Our lab’s long-term goal is to create a novel gene therapy-based therapeutic to preserve and restore healthy vision for patients suffering from diseases that cause irreversible blindness. In particular, we study a disease called Retinitis Pigmentosa (RP)...
We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...
Certain basic cognitive processes are central to navigating the world around us. Attention, for example is important for almost all of our conscious actions, yet there's so much we still don't know about the cell types and circuits that support it...
Our lab studies the molecular mechanisms of sensory transduction, seeking to understand how animals detect the physical and chemical cues from their environment and transform them into cellular signals. In particular, we focus on the sense of smell in...
The human brain—and the diseases that afflict it—present unique challenges for experimental study, chief among them being tissue availability (only at postmortem) and profound cell non-autonomy in tissue function. Our lab seeks to develop technologies...
Restoring lost function after spinal cord injury or other types of CNS injuries is a major challenge of contemporary neuroscience. A key culprit of functional deficits is the disruption and/or dysfunction of axonal connections connecting different parts...
Vik Khurana M.D. Ph.D. is the inaugural incumbent of the Tracy T. Batchelor Endowed Chair in Neurology at MassGeneral Brigham, Chief of the Movement Disorders Division at Brigham and Women's Hospital and Associate Professor of Neurology at Harvard Medical...
