The Abudayyeh-Gootenberg lab, based at the Mass General Brigham Gene and Cell Therapy Institute, Beth Israel Deaconess Medical Center, and Harvard Medical School, is dedicated to exploring programmable systems in biology for the development of molecular...
Fundamental questions remain unanswered about pancreas biology and the earliest processes that lead to pancreatic cancer, including:
• What are the transcription factor networks and epigenetic barriers that maintain normal cell identity in the exocrine...
Vik Khurana M.D. Ph.D. is the inaugural incumbent of the Tracy T. Batchelor Endowed Chair in Neurology at MassGeneral Brigham, Chief of the Movement Disorders Division at Brigham and Women's Hospital and Associate Professor of Neurology at Harvard Medical...
The objective of our research is to understand the molecular and cellular mechanisms whereby intracellular membrane lipid composition regulates lipid and glucose metabolism in health and disease. Phosphatidylcholines (PC) are the most abundant lipid class...
Our lab aims to understand the in vivo functions of certain genes identified in neurodegenerative and developmental disorders of the human brain such as schizophrenia, Alzheimer's disease, lissencephaly, autism and mental retardation. We use a variety of...
Overview
The Wesemann laboratory uses mouse genetics, human studies, cellular biology, single cell transcriptomics, and computation to elucidate underlying features and elasticity of antibody recognition capacity. We study the dynamic regulation...
We are exploring pathogen-host interactions, particularly in the context of animal models relevant to human infection of clinically important enteric pathogens including Vibrio cholerae, Vibrio parahaemolyticus and enterohemorrhagic Escherichia coli (EHEC...
1. Using data from a high-throughput experimental assay, we have developed a computational algorithm that predicts the genotypic outcomes of template-free CRISPR/Cas9 genome editing. This modeling has uncovered that CRISPR/Cas9 outcomes are highly...
Our laboratory is interested in the biochemistry and molecular and cell biology of neuronal degeneration during aging of the mammalian brain, particularly in Alzheimer's (AD) and Parkinson's (PD) diseases. The laboratory originally developed methods for...
Immune-mediated diseases such as lupus or rheumatoid arthritis are not caused by an isolated insult resulting in a single dysfunctional gene or pathway, but rather a systemic dysregulation of multiple genes and pathways. Our group uses methods in...
