Chronic pain and headache disorders are two leading causes of disability world-wide. Improving treatments for these conditions is a major focus of my lab as well as my clinical practice as a neurologist. The experience of pain begins with specialized...
The research in our lab focuses on tissue-responsive nanomaterials for biomedical applications and is dedicated to leveraging materials science and engineering, imaging and basic science to improve human health. We develop smart material platforms that...
The Gupta Lab studies the gene regulatory networks that cause vascular disease using high-throughput CRISPR screens. We have expanded Perturb-seq methods to cover all 20,000 genes and identified co-regulated gene networks using AI/ML methods. For coronary...
The Tsai Laboratory studies transcription factor protein stability and developing new methods to target transcription factors for degradation to treat disease. Many proteins are removed through ubiquitination and proteasomal degradation; recent studies...
We study how Epstein-Barr virus causes nearly 1% of all human cancers and also serves as the major viral trigger for autoimmune diseases, in particular multiple sclerosis.
A fascinating and incompletely understood aspect of EBV pathogenesis is that it...
We are interested in the fundamental mechanisms of neurodegenerative disorders like Alzheimer’s disease. Over the past century-plus, research has revealed specific proteins that misfold and are deposited in neurodegeneration, and recent discoveries have...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the goal...
My lab explores signal transduction pathways in the cells and tissues of the cardiovascular system. We have a particular focus on applying biochemical methods and cell imaging approaches using informative biosensors to probe nitric oxide synthase...
The focus of my laboratory is to elucidate how deregulated cell signaling drives cancer. To achieve this we have been taking a multi-faceted approach; combining mouse modeling techniques with basic biochemical and cell biological studies. One of the most...
Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...
