Assistant Professor of Stem Cell and Regenerative Biology
Cells in complex mammalian tissues, such as the brain, are spatially organized and dynamic, yet almost all genomic tools lack temporal and spatial resolution. Our laboratory, at the Broad institute, sets out to build a set of tools which will bridge single-cell genomics with space and time – to enable discoveries of where cell types are localized within intact tissues, when relevant transcriptional modules are active. To do this, we are developing novel technologies at the intersection of microscopy, genomics, synthetic biology, and bioinformatics. We are applying these tools to learn organizational principles governing neurodevelopment, and cellular mechanisms of disorganization during neuronal injury and disease.
Broad Institute of MIT and Harvard||415 Main Street|Cambridge, MA 02141