Our lab tries to understand the molecular mechanisms underlying pluripotency and nuclear reprogramming. Pluripotency denotes the ability of cells, such as embryonic stem (ES) cells, to give rise to all cell types of the mammalian body, while nuclear reprogramming is the dedifferentiation of a specialized cell back into a pluripotent state. Reprogramming does not normally occur in vivo but can be achieved experimentally by nuclear transfer, ES cell-somatic cell fusion and by directly inducing embryonic genes in somatic cells, generating so-called induced pluripotent (iPS) stem cells.
We are studying these processes functionally by establishing transgenic and knock-out mice and by manipulating murine and human ES cells. Combined with genome-wide approaches including RNAi and chemical screening we aim to dissect the mechanisms of pluripotency and epigenetic reprogramming. Ultimately, we hope that our research will aid in attempts to generate custom-tailored cells for treating and understanding disease.
Sihem Cheloufi, PhD, Postdoctoral Associate
Benjamin Schwarz, MD/PhD, Postdoctoral Fellow
Ryan Michael Walsh, PhD Student (BBS)
Abby Sarkar, PhD Student, (BBS)
Jiho Choi, PhD Student, (BBS)
Marti Borkent, Visiting PhD Student (Erasmus University, Rotterdam)
Aaron Huebner, PhD, Postdoctoral Fellow
Justin Brumbaugh, PhD, Postdoctoral Fellow
Kyle Flaherty, Undergraduate Student (Harvard)
Caitlin Murphy, Administrative Assistant
Richard B. Simches Research Building, CPZN 4242
185 Cambridge Street
Boston, MA 02114