My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1 diabetes. As a 2013 BBS grad, I understand what it takes to have a successful Ph.D. experience.
The...
Our laboratory studies the mechanisms of epigenetic regulation of DNA virus infection. We are interested in the mechanisms by which human cells sense foreign DNA in the cell nucleus and activate transcription of innate response genes and epigenetically...
Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular our studies have help define molecular mechanisms that underlie the cell's sorting machineries mediated by the clathrin...
Our studies have spanned evolutionarily conserved pathways of innate immunity, the integrative physiology that connects infection and immunity with cellular and organismal responses to stress, and how interactions with microbes influence neuronal...
My laboratory has long been interested in the interactions of microbes, both commensals and pathogens, with the immune system. Our overall major research focus has been on bacterial carbohydrates. In studies innovatively integrating structural...
For many years our research group has been interested in the molecular mechanisms of various antibiotics and the fundamental cellular processes they inhibit. We have primarily focused on drugs that target bacterial cell wall biosynthesis, including the...
Ancient signaling pathways lie at the base of the initiation of immunity, serving to transmit signals from Pattern Recognition Receptors (PRRs) to trigger the activation of anti-microbial defenses. All PRRs, which evolved to detect potentially pathogenic...
Elucidating the Molecular Principles of Self vs Non-self RNA Discrimination by the Immune System
Correct discrimination of “self” vs “non-self” nucleic acids by the innate immune system is essential for host defense against viral infection. A failure to...
The increasing emergence of bacterial strains resistant to antibiotics is far outpacing our ability to develop novel therapies to treat these infections. Further, the methodologies used to both diagnose infection and predict appropriate courses of...
Our laboratory uses bacteria to study fundamental mechanisms of transcription regulation, as well as the biology of prions. With an emphasis on the development of genetic tools, our work also encompasses biochemical, structural and microscopy-based...
