Immune cell modulation is an attractive strategy for the treatment of inflammatory conditions. Inflammation is critical to protecting us from dangers within (e.g. cancer) and without (e.g. microbes). But inflammation also drives much human pathology and diseases, including autoimmune diseases and neurodevelopmental disorders.
The Huh lab is interested in identifying host- and bacteria-derived small molecules that control inflammation in the mammalian gut. We are also interested in uncovering mechanisms by which nuclear hormone receptors control immune cell differentiation and function. Finally, we are trying to uncover the dynamic interplay between the host immune system and gut-residing bacteria in pregnant mothers and understand how such interactions dictate neural development of the developing fetus.
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