The Ubiquitin Proteasome System (UPS) is involved in virtually any cellular process and frequently implicated in human pathologies. Ubiquitin, through the action of a three-enzyme cascade (E1, E2 and E3), becomes attached to substrate proteins. The...
The lab is interested in the ubiquitin-proteasome pathway. There are several ongoing projects:
Usp14 is a proteasome-associated deubiquitinating enzyme. We study both the mammalian (USP14) and yeast (Ubp6) forms of the enzyme. USP14/Ubp6 is a powerful...
The molecular mechanisms underlying neurodegeneration in human disorders like Alzheimer's disease and Parkinson's disease remain mysterious, in part because genetic analysis in patients and vertebrate models is laborious. Disease models in simpler...
The Ebert laboratory focuses on the molecular basis and treatment of hematologic malignancies, with a particular focus on myelodysplastic syndromes (MDS). In large-scale genetic analyses of patient samples, the lab has identified somatic mutations that...
The Dvorin Laboratory is part of the Division of Infectious Diseases at Boston Children's Hospital, the primary pediatric teaching hospital of Harvard Medical School. The research in our laboratory investigates the molecular pathogenesis of infection by...
Successful infection of a host organism by a bacterial pathogen depends critically on its ability to make the appropriate virulence factors at the right time and place. This is achieved through the coordinate regulation of virulence genes, the expression...
The goal of my lab is to understand the regulatory relationship between cellular signaling pathways and metabolic pathways. We are particularly interested in the PI3K (phosphoinositide-3-kinase) signaling pathway which is a major regulator of glucose and...
Our lab focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem cells, and common mechanisms in reprogramming and cancer. Our subgroups study:
Our laboratory examines the molecular signaling pathways which regulate the DNA damage response in mammalian cells. Disruption of these pathways, by germline or somatic mutation, leads to genomic instability, cellular sensitivity to ionizing radiation...
The D'Amore laboratory has a long-standing interest in the regulation of vascular development and pathology. One major area has involved investigating the role and regulation of VEGF in adult vascular and non-vascular cells. More recently, her laboratory...
